Gina and Nate
The two hate each other a lot, especially in early May 2014. It was when Nate swore. They have very rare respect for each other, and when they do get along, it could be what most people say love-hate, but that happens in accidents.
Jenny and Nate
We all know Nate Wright has an ongoing crush on Jenny Jenkins. But on her side, she dislikes him, but it is unknown if she really hates him. Jenny was once nice when she tried to befriend Nate ( it failed because Nate said close friends). In the books she is nicer because she does not physically hurt him as in the strips, and she was only mean in Big nate strikes again and "Big nate in the zone." Typically Nate is stupid sometimes.
Artur and Nate
On Nate's side, he is only slightly mean to him. It is unknown if Nate definitely hates him, as Artur is very nice.
Gina and Artur
They never interact, but Nate tried to get them together once. They both share many similarities.