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Femme Fatality is a comic book series that Nate Wright reads. Some of the characters in the comic series include Femme (female protagonist) and Doctor Jackal (a very evil villain). Although we do not know exactly what it is about, it is mentioned multiple times in the "Big Nate" series. and it can be assumed that it is action-oriented.
Nate Wright was into Red Sonya when he discovered the series. He is shown to have a crush on the hero, Femme. He also introduced the series to Peter, his book buddy. Before Martin Earl Wright admitted he liked Femme Fatality, he had been secretly been reading Nate’s issues of them.